Myrtle Beach made it a clean sweep over the Florence schools.
Daiquone Ford scored four touchdowns as the Seahawks defeated Wilson 42-0 on Saturday at Memorial Stadium in the Region VIII, Class 3A opener for both teams.
With the win Myrtle Beach is 3-0 against the Florence schools this year.
"For the first time maybe since the first game of the year, we really just put everything together," Myrtle Beach coach Mickey Wilson said. "We are starting to peak and that's what you want to do in region play and we hope to continue to do that in the next couple weeks."
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The Seahawks (5-1, 1-0) had to rally in victories over South and West Florence, scoring in the final minutes of both games. But no rally was needed against the Tigers as the Seahawks scored on their first six possessions of the game.
"We got behind the eight ball early and never could climb out of it," Wilson coach Darryl Page said. "Myrtle Beach had a great game plan and executed it very well."
Ford was the catalyst for the Seahawks and finished with 148 yards on the ground and three touchdowns. He also caught two passes for 59 yards and a touchdown.
Quarterback Mitch Campbell, staring his third game for the injured Everett Golson, threw for 260 yards and three touchdowns.
"Mitch and Daiquone really put us on their shoulders tonight and carried us tonight," Wilson said. "We needed to come out in region play and get this win."
Donte Sumpter caught five passes for 126 yards and two touchdowns
Golson was at the game in a walking boot and Wilson said he would see as next week goes along if he will play against Socastee, which Myrtle Beach hosts on Friday.
The Seahawks are 4-0 since Golson was injured in the second game of the year against Byrnes. Myrtle Beach's offense hasn't missed a beat and outgained Wilson 441-87.
The loss was Wilson's fourth in its last fifth games with three of them coming by 20 points or more.
"You are going to go through some highs and lows and right now this is a low for us right now," Page said. "We just got to fight through this and eventually it is going to break."
Wilson will travel to St. James.