DURHAM, N.C. — Quinn Cook scored a career-high 27 points and No. 1 Duke held Clemson to its lowest-scoring half in 12 years in a 68-40 victory over the Tigers on Tuesday night.

Ryan Kelly added 12 points in the first half but sat out the second with what team officials said was a right leg injury.

The Blue Devils (15-0, 2-0 Atlantic Coast Conference) shot 48 percent, built a 42-31 rebounding advantage and pulled away down the stretch to improve to 58-4 at home against the Tigers.

Devin Booker had 12 points and 15 rebounds for Clemson (8-6, 0-2), which had season lows for points and shooting percentage (28 percent) and shot 12 percent in its brutal first half.

The Tigers had just 10 points at halftime, their fewest since scoring nine against Wake Forest in 2001.

Still, Clemson made things interesting briefly in the second half, closing to 34-22 on Adonis Filer’s layup with 15 1/2 minutes left.

That came after Duke’s third consecutive turnover in the backcourt, and had an incensed coach Mike Krzyzewski thrusting his fist on the court as he called a timeout.

Tyler Thornton rattled in a 3-pointer two possessions later, and Seth Curry followed that with a jumper to push it to 39-22 and put Duke back in control. Clemson didn’t get closer than 14 points the rest of the way.

Mason Plumlee finished with 13 rebounds – his ACC-leading 10th double-figure rebounding game this season – for the Blue Devils, who opened with 15 wins for the sixth time under Krzyzewski.

For Cook, it was a strong bounce-back performance after he missed all 11 of his shots – but had a career-high 14 assists – three days earlier in a rout of Wake Forest. He was 12 of 16 in this one with three of Duke’s eight 3-pointers and easily surpassed his previous high of 17 points two months ago against Minnesota.

Yet neither he nor anyone else could make anything early in this one. The teams combined to miss their first 16 shots over the first 5 1/2 minutes.

But while Duke eventually warmed up, the Tigers spiraled to their coldest half in years.

Clemson was 3 for 25, went nearly 8 minutes between field goals, managed just one basket over the final 12 1/2 minutes and didn’t reach double figures until 2:39 before the break – all tough numbers to overcome for a team looking for just its third victory against a No. 1 team and first since 2001.

Kelly scored 10 points during a 16-2 run that included 13 straight points for Duke – and by halftime, he had outscored the entire Clemson team.

State

•  Appalachian State 50, (at) Wofford 49 | Tevin Baskin hit the go-ahead layup to cap a six-point spurt and added a crucial block with 4 seconds left as Appalachian State held Wofford scoreless for the final 6:57 to win.

The Mountaineers (5-8, 1-1 Southern Conference) led 36-27 early in the second half, but Spencer Collins scored seven straight points as part of an 8-0 Terriers run.

Wofford (6-9, 0-2) used another 8-0 burst to lead 47-40, and Collins, who led the Terriers with 13 points, hit a jumper with 6:57 left to make it 49-44. Those were Wofford’s final points, with the Terriers missing 10 shots, including Justin Gordon’s layup attempt blocked by Baskin.

Tab Hamilton started the Appalachian State comeback with a jumper with 5 minutes remaining, followed by Mike Neal’s layup with 4:18 left and Baskin’s layup with 2:32 to go.

Baskin and Nathan Healy led the Mountaineers with 10 points apiece.

Top 25

•  (At) No. 10 Missouri 84, Alabama 68 | Jabari Brown hit a career-high five straight 3-pointers after an early miss and Phil Pressey responded from a shaky first half with 11 points and 13 assists, leading Missouri to a victory over Alabama in its SEC debut.

Trevor Releford had a career-best 26 points with three 3-pointers and topped 1,000 points for Alabama (8-6, 0-1), which has lost six of eight. Coach Anthony Grant lost for the first time in seven career conference openers, three at VCU and four at Alabama.

Brown scored a career high 22 points on 7-for-11 overall shooting, three days after making only one of nine attempts in a two-point victory over Bucknell. The Oregon transfer has scored in double figures four of five games since becoming eligible at the semester break.

Earnest Ross added a season-best 19 points for Missouri (12-2, 1-0).

•  (At) No. 13 Creighton 91, Drake 61 | Ethan Wragge matched career highs with 22 points and six 3-pointers and Creighton got off to a blistering start on its way to a victory over Drake.

Doug McDermott added 16 points, Jahenns Manigat had 13 and Grant Gibbs 10 for the Bluejays (15-1, 4-0 Missouri Valley Conference), who won their ninth straight game.

Creighton has won 71 straight against opponents .500 or worse, and it was apparent early that the streak was in no jeopardy. The Bluejays, who made a season-high 16 3-pointers, led by 30 points in the first half and by 35 late in the second.

Joey King scored 17 points and Jordan Clarke and Micah Mason had 11 apiece for Drake (6-9, 0-4).

Women’s Top 25

•  No. 2 Notre Dame 75, (at) South Florida 71 (OT) | Skylar Diggins scored four of her 19 points in overtime, helping Notre Dame overcome cold shooting and hold off South Florida for a victory.

Natalie Achonwa had 20 points and Jewell Loyd finished with 18 points and 13 rebounds for the Fighting Irish (13-1, 2-0 Big East) in their first game since handing then-No. 1 Connecticut its first loss of the season. Kayla McBride was limited to 12 points on 4-for-14 shooting, but keyed a second half surge that helped Notre Dame take its first lead since early in the game.

Andrea Smith tied a career high with 33 points and 11 rebounds for USF (11-3, 0-1), including her team’s last nine points of regulation and first four of overtime. Smith’s twin sister, Andrell, had 15 points before fouling out less than a minute into the extra session, and Inga Orekhova added 13.

•  (At) No. 15 Louisville 66, Rutgers 57 (OT) | Antonita Slaughter drained a 3-pointer to open overtime and finished the extra frame with six of her 10 points as Louisville earned its first Big East Conference win, topping Rutgers.

Shoni Schimmel set a season-high for the second straight game with 21 points, none bigger than a jumper with 6 seconds left in regulation to force a 52-all tie that carried into overtime.

Slaughter hit her 3-pointer 13 seconds into overtime, and Sara Hammond followed with a trey about a minute later for a 58-52 lead. Schimmel tacked on a jumper and Slaughter a free throw for a 61-52 lead with 40 seconds to play.

Monique Reid added 18 points for Louisville (13-3, 1-1).

Erica Wheeler paced Rutgers (9-6, 0-2) with 18 points. Monique Oliver, who has been battling a sprained left ankle, scored 10 points with nine rebounds in 36 minutes.