DETROIT — Matthew Stafford threw a 5-yard touchdown pass to Kevin Smith with 10 seconds left, lifting the Detroit Lions to a 27-23 win over the St. Louis Rams on Sunday.

Stafford made up for a shaky game by leading an 80-yard, nine-play game-winning possession that included three passes of at least 18 yards.

Sam Bradford directed a go-ahead drive that set up Greg Zuerlein's 46-yard field goal and put the Rams ahead 23-20 with 1:55 left. But coach Jeff Fisher's debut ended with a loss because the Rams could not shut down Stafford in the end.

Stafford had three interceptions before halftime for the first time in his four seasons. The Rams scored 13 points off Stafford's turnovers, including Cortland Finnegan's 31-yard return for a TD that gave them a 13-7 lead late in the first half.

•  (At) Chicago 41, Indianpolis 21 | Jay Cutler threw for 333 yards and two touchdowns and Michael Bush added a pair of scoring runs to spoil quarterback Andrew Luck’s debut.

Brandon Marshall had nine catches for 119 yards and a touchdown in his first game since being reunited with Cutler, and Matt Forte ran for 80 yards and a score.

Luck finished his first NFL game 23 of 45 for 309 yards with a 4-yard touchdown pass to Donnie Avery early in the fourth quarter. He also was intercepted three times – twice by Tim Jennings – in an up-and-down effort as he steps in for the departed Peyton Manning.

Reggie Wayne caught nine passes for 135 yards. But it was a familiar result for a team with new management and a new coach in Chuck Pagano.

(At) Minnesota 26, Jacksonville 23 (OT) | Rookie Blair Walsh kicked four field goals, including a 55-yarder as regulation time expired and another one in overtime, and Adrian Peterson returned from a left knee injury to lift the Vikings.

Peterson ran 17 times for 84 yards and two touchdowns for the Vikings, who led for most of the second half until Blaine Gabbert’s 39-yard touchdown heave with 20 seconds left in the fourth quarter put the Jaguars back in front.

For the first time since the NFL’s new overtime scoring rule was installed last season, the first team on the board didn’t immediately run off the field a winner.

After Walsh’s 38-yard kick, the Vikings had to play defense again while the Jaguars had their chance to match. But Gabbert was hurried into a fourth-down overthrow, spoiling the debut for new Jaguars coach Mike Mularkey.

• (At) Detroit 27, St. Louis 23 | Matthew Stafford threw a 5-yard touchdown pass to Kevin Smith with 10 seconds left.

Stafford made up for a shaky game by leading an 80-yard, nine-play, game-winning possession that included three passes of at least 18 yards.

Sam Bradford directed a go-ahead drive that set up Greg Zuerlein’s 46-yard field goal and put the Rams ahead 23-20 with 1:55 left. But coach Jeff Fisher’s debut ended with a loss because the Rams could not shut down Stafford in the end.

Stafford had three interceptions before halftime for the first time in his four seasons. Cortland Finnegan had a 31-yard interception return for a TD that gave the Rams a 13-7 lead late in the first half.

• (At) New York Jets 48, Buffalo 28 | Mark Sanchez threw three touchdown passes, including two to rookie Stephen Hill, and the Jets eased concerns about their offense.

The Jets sprinkled in their wildcat package with Tim Tebow, who was mostly quiet but recovered a late onside kick by Buffalo, and Jeremy Kerley had a touchdown catch and a punt return for a score. Antonio Cromartie also took one of New York’s three interceptions of Ryan Fitzpatrick to the end zone.

It was the most points the Jets have scored in a season opener. That’s from a team that had many wondering what to expect after the first-team offense failed to score a TD in the first three games of the preseason.

Meanwhile, Mario Williams, the Bills’ big free agent signing, was quiet as the Jets’ offensive line protected Sanchez all game.

• (At) Houston 30, Miami 10 | Arian Foster had two touchdown runs, Matt Schaub threw a TD pass to Andre Johnson, and Houston’s defense dominated rookie Ryan Tannehill and Miami.

Tannehill threw three interceptions in a 6-minute stretch late in the first half, and the Texans opened impressively in what they believe can be a Super Bowl season.

Schaub threw for 266 yards in his first action since fracturing his right foot in Week 10 last year, and Johnson finished with 119 yards receiving. Texans defensive end J.J. Watt deflected two passes that resulted in interceptions and also had 1 1 / 2 sacks.

Marcus Thigpen returned a punt 72 yards for Miami’s touchdown. The Dolphins gained only 275 total yards in coach Joe Philbin’s coaching debut.

• New England 34, (at) Tennessee 13 | Tom Brady threw for 236 yards and two touchdowns, and the defending AFC champions won easily.

Brady may have suffered a broken nose when he was sacked in the second quarter by Kamerion Wimbley, but he didn’t miss a play.

The Patriots ruined Jake Locker’s debut as Tennessee’s starter, sacking him twice and forcing two turnovers. Rookie Dont’a Hightower returned Locker’s fumble 6 yards for a TD in his own debut, and Stevan Ridley ran for 125 yards and a TD.

Also, Locker came out of the game after hurting his left shoulder when tackling safety Patrick Chung on a fumble return. He was replaced by Matt Hasselbeck.

• Atlanta 40, (at) Kansas City 24 | Matt Ryan threw for 299 yards and three touchdowns, one of them to Tony Gonzalez in his return to Kansas City.

Ryan also ran for a TD, while Julio Jones caught six passes for 108 yards and two scores.

The Falcons took advantage of a Chiefs defense missing four starters. Pro Bowl linebacker Tamba Hali was suspended for an unspecified violation of the league’s substance-abuse policy, and three others were injured.

Kansas City matched Atlanta most of the first half, trailing 20-17 at the break. But a missed field goal by Ryan Succop early in the third quarter proved to be the turning point.

Matt Cassel finished with 258 yards passing for Kansas City, but also threw two interceptions and lost a fumble.

• (At) Arizona 20, Seattle 16 | Kevin Kolb replaced injured John Skelton and led Arizona on the deciding touchdown drive, throwing 6 yards to Andre Roberts for a score with 4:59 to play.

Aided by two pass interference penalties, Seattle drove to the Arizona 4 in the final seconds. But rookie Russell Wilson threw three straight incompletions and the Cardinals held on.

Adding to the confusion, Seattle appeared to have called a timeout when it had none remaining, but that turned out to be a mistake by the replacement officials working the game.